When Jeredy and the Monsuno Five attempt to conceal the last Failsafe Device deep in the sewers of Isemon, they suspect that they are being followed. It soon becomes clear that whatever is on their trail is not just following them.

Our three heroes venture into the big city of Axistown to search for a lead on Jeredy. Soon they meet a wealthy old woman who sends them into the Underground on Jeredy's trail, but the Underground turns out to be a Fight Club for Monsuno.

Chase and the others crash land in the jungle where they are joined by Jon Ace, freshly resigned from S.T.O.R.M., and on the run himself. Unbeknownst to them, they are being hunted by the crazy Dom Pyro of the Eklipse Organization.

After desperately attempting to regain his Monsuno Sight, Beyal falls into a catatonic state. Concerned, Chase and the gang take Beyal to Master Ey at Tiger's Lair, who tells them that they must travel to the icy Cave of Convergence.

While following Dax, the Core-Tech team happens to catch sight of Jeredy Suno, when they are suddenly attacked by Dark Spin mercenaries. Before being separated from his son once again, Jeredy gives Chase a new Monsuno named Evo.

Desperately in need of key information to help them on their quest, our heroes travel to Mandala, to the Ancient Library of Tebab, where they become captured by the evil Bookman, and encounter a young controller named Beyal.

Chase and the group, along with the Dawnmaster, One-Eyed Jack, and his Desert Wolves, all become trapped in Dr. Klipse's lab. Dr. Klipse has developed weapons of mass destruction powered by a new Monsuno Fusion Core Reactor.

After Beyal convinces Chase that Dax should be the fifth member of the group, things take a turn for the worse when Dax sells them out, even helping Charlemagne capture them. However, things are not always what they seem.

As Chase and the group contemplate rescuing Jeredy and Ace from Dr. Klipse, Klipse reveals his ultimate plan to Jeredy. If Jeredy wants to save his son, the good doctor must perform his own scientific experiments. On Ace.

Chase has another one of his intense dreams, only this time, he does not believe it was just a dream. Chase firmly believes that he is having visions about a massive natural disaster that is coming, an impending disaster caused by Monsuno.