A year has passed and there are new additions to the March family, but there is worry all around as Beth's health and spirits flag. Amy is chosen over Jo to go on a tour of Europe. Jo flees to New York to pursue her career, but devastating news from home cuts Jo's adventure short. The family reunites upon Amy's return, which is made more joyful by unexpected news and a surprise visitor.

As Marmee waits by her husband's sickbed, the March sisters must learn to cope without their parents. Together they face unrequited love, hurtful rumors, trouble at school and the toll of sickness. Meg and John Brooke's relationship develops, as do Jo's literary prospects. Jo grows anxious as the future for her and her loved ones seems fraught with challenges.